https://www.gruberlabutsw.org/contact-us daily 0.75 2023-09-10 https://www.gruberlabutsw.org/science daily 0.75 2022-08-13 https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/1626730603280-OXKGZPJ91A0FPVK4OLP4/Investigational+compound+docked+into+the+acetyl-CoA+binding+site+of+HAT1+crystal+structure Our Science - Designing chemical tools to probe HAT1 Can we design a HAT1 inhibitor? Can we engineer proteogenomic tools to disrupt the HAT1 pathway? We need better tools to study metabolic-epigenetic crosstalk. There have been few chemicals discovered that can modulate the HAT1 pathway. We are using principles of drug discovery, high-throughput screening, enzymology and cheminformatics to identify and develop bonafide HAT1 inhibitors. This is transdisciplinary work that bridges medicinal chemistry, protein biochemistry, and biophysical approaches like crystallography. https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/1626732247274-W26J34O92Q3BBO2ULVQH/VISTA%2B+triple-negative+breast+cancer Our Science - The VISTA immunoreceptor in triple-negative breast cancer Epigenetic profiling allowed us to identify a novel immunoreceptor (VISTA) present on the surface of many human triple-negative breast cancers. VISTA bears homology to PD-L1 and is therefore a target of interest for cancer immunotherapy. We are characterizing how VISTA controls the growth of human breast cancers, specifically focused on molecular biology, biochemistry and cell biology. Finally, we are interested in human clinical trials that target VISTA. https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/1626727446951-D6RVWAM3X9OIUDL7Y9CX/Nucleosome+metabolic+cycle Our Science - Controlling the Epigenome How are nucleosome made and can we control them? Through our studies on HAT1 we have characterized histone control elements. These genome sequences control how and when nucleosomes are made, but the details remain murky. Using principles of retro-synthesis, genome design and reverse genetics we seek to de-construct and re-construct how histones are made and how they get assembled into chromatin. This should lead to new technologies to control the epigenome and new therapeutics to combat cancers. https://www.gruberlabutsw.org/people daily 0.75 2025-04-28 https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1618497259178-6XJGK9GR6YAVBQL5L519/20140301_Trade-151_012-2.jpg People https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694583486-2PQT0LQ193RL7MCB6DX4/20140228_Trade+151_0046.jpg People https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1607694644871-IC85FNH781UNZSZEGHDR/Aro+Ha_0428.jpg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/1658410856683-7YFLGCYZEIPVT91YHM7W/image_6487327+crop.jpeg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/1658411009716-Z1G0HMRHKRN1M2CUSUJY/Priyanka_photo.jpeg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/1658411635203-9A2OH2C75QACFQ00G3MA/Alan-1.jpg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/79c8d658-9e05-449e-86ee-23d010243b2b/IMG_4475.jpg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/faba9b55-5a74-4731-ac89-89158a055549/VEzenwa+Pic%5B83%5D.png People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/1ffc2c8a-dc76-4466-85ff-1cd6bbdc5133/HG_picture.jpg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/8eec9c88-6726-401f-8bf7-e0ae1bedb3c8/tempImageoHNBFh.jpg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/4e607c56-7d29-40cb-bd5b-2b1ece4c374a/IMG_5142.JPEG People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/26a2c277-00d6-4be4-ac90-4165f8770ec5/Benny_lego_movie.jpeg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/a23741bf-8f1a-4e66-939d-7e1e3552b106/DIxon_profile+copy.jpg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/9354c766-aa86-4fe5-a9e2-f9f16c7fb009/IMG_0491-+KK.jpg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/e0cd6687-81d6-4d1d-9d3f-1fab5e818a28/Fatima+crop+2.jpeg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/46506e4a-0375-4b9c-b976-bf89fd8f7838/Caiden_Image+crop.jpeg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/03e8b65d-b94d-4243-b840-8d241eaf76a0/Lavanya_image.jpg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/6a62dbe9-2e5f-4d41-a0dd-3f32ab3468c1/WhatsApp+Image+2024-07-09+at+6.31.57+PM.jpeg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/f5ad473a-aa37-493f-b888-018aa28a1a57/Abbas_photo.jpeg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/d50ad331-6df2-4511-92b3-56572cc7bd2b/PHOTO-2024-07-10-12-14-19.jpg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/7dcde281-b066-4c4c-a6bb-2ad4907f031d/tempImageJY2d4g.jpg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/a5beb107-9645-4128-9d55-e1e03ce53709/Tarah_Brown_lab+webpage+image.jpg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/f618ddd2-1f1e-416d-92b2-99b28a2f5973/ishrat_running_emoji.png People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/c8f07794-8232-4011-a941-2cb2c047a55f/Van_photo.jpeg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/ac57b583-19ab-4b73-8ed2-68b56a33465c/1M5A2389 People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/7a84d23e-0447-40bd-8f50-529763d3ee05/Wendy_picture.jpeg People https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/096b2965-a0e1-4e8a-a1a0-90a0025b0a9e/imagejpeg_1.JPG People - Joshua Gruber, MD, PhD Dr. Gruber is an Assistant Professor in the Department of Internal Medicine, Division of Hematology/Oncology and the Simmons Comprehensive Cancer Center. He is also appointed to the Cecil H. and Ida Green Center for Reproductive Biology Sciences and the Department of Molecular Biology. https://www.gruberlabutsw.org/home daily 1.0 2023-09-10 https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/1626733576596-T31N463CD9O6I5BYH4RS/HAT1+crystal+structure+with+acetyl-CoA+binding+site+highlighted+in+red The Gruber Lab @ UTSW - Make it stand out HAT1 (2P0W) with acetyl-CoA binding site in red https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/1626749525299-JX7THQEZFX4D4LB99EYZ/VISTA+is+expressed+on+APC%2FDCs%2C+lymphocytes+and+tumor+cells The Gruber Lab @ UTSW The VISTA immunoreceptor resembles PD-L1 and is a target for cancer immunology https://www.gruberlabutsw.org/publications daily 0.75 2026-03-30 https://www.gruberlabutsw.org/lab-culture daily 0.75 2025-03-20 https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/1646155477715-JB8YI1CI3F8U4BS7MY68/tempImageerfADu.gif Lab Culture https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/1646155731709-G1AN3M8QGBOXR572EMNS/tempImage1hGKBN.gif Lab Culture https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/1646155785099-7ID985XO6AJDK4F67JDC/tempImageelayVo.gif Lab Culture https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/264b8493-01c3-420b-b9fa-5826dd08cada/tempImage3Idylx.png Lab Culture https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/a6014f87-b5ad-4753-b1f2-8536c7cef1e1/tempImage3ecMZC.png Lab Culture https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/1622ab20-c077-4b3d-89e6-128ffc17b0a5/tempImagea21zMY.png Lab Culture https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/67ef1533-4e46-4c61-8394-625db893014c/tempImagerr0i7e.jpg Lab Culture - Make it stand out State Fair 2023 https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/dda3925f-4d0e-46cf-b61e-e19a899edf06/1M5A2359-wholeLab.jpg Lab Culture - Make it stand out Gruber Lab Sandbox VR 2023 https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/2f7255d5-2799-4efc-b9fb-9e0f27a61b38/1M5A2365+-+SBVR+zoom.jpg Lab Culture - Make it stand out with space guns https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/ae33bc6c-268d-4316-900c-4028a534b9cb/1M5A2351+-+elite+warriors.jpg Lab Culture - Make it stand out elite warriors https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/53ff056d-3101-4c04-abaf-1cdb9c3d6171/1M5A2375+-+dinner+after+shootout.jpg Lab Culture - Make it stand out celebrating destruction of an alien horde https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/36beb38e-b4eb-4c53-8bcc-07f8ae61eba7/tempImagexyUmpG.jpg Lab Culture - Make it stand out Escapology 2022 - Gruber + Ligorio labs joint retreat https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/0ec31d73-2aa5-4cf5-b06b-95e2bcb5a0ae/tempImagepfzOFB.jpg Lab Culture - 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Make it stand out fashion https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/fad90085-6ed3-4288-b445-99dec553cbd9/tempImage7jJZ6M.jpg Lab Culture - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/6d4c985d-6acf-4041-a315-75e523d1ecd2/1M5A2382+-+tasty.jpg Lab Culture - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/06088177-2718-4edd-8797-c8b2c5270c93/tempImage9c7fBg.jpg Lab Culture - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/e992e4de-93b8-472f-853c-d2a2015d0ac4/tempImageE2uKGI.jpg Lab Culture - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/f8544080-32a9-4eba-bd9e-38a4b86404fa/tempImageCrUCub.jpg Lab Culture - Make it stand out 14th floor sunset https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/85e0f228-5d05-4464-afff-94577a9773a2/IMG_1733+-+sailboats.JPG Lab Culture - Make it stand out white rock https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/ba905dd9-cc5a-488c-b62a-d52428f3fd50/tempImageIQE2jF.jpg Lab Culture - Make it stand out very valuable enzymes https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/fdfa4cd9-5f9c-405d-b651-4dab9c5a0e6e/tempImageeFQHOt.jpg Lab Culture - Make it stand out Human centrifuge https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/fb0207f6-0ac4-4e0e-aa5a-343399d32410/tempImages65cRO.jpg Lab Culture - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/27c1ebbd-6b37-4fc2-8b84-bbe74b99f3af/tempImagevck9Hv.jpg Lab Culture - Make it stand out white rock https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/359fc58c-2ef1-4f6a-9497-023f090c391b/tempImagewuKxdL.jpg Lab Culture - 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Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/9c8f9308-c17f-4fab-90e7-c018cc899479/tempImage5IcGHv.jpg Lab Culture - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/457e34bd-4b23-440e-8108-71236e2c4755/tempImageIX3MdB.jpg Lab Culture https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/a792808e-cb04-4702-8da7-7b9438993f5b/tempImage7ogT8R.jpg Lab Culture https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/58132b02-c369-41e7-a4f8-351fe29a7f74/tempImageLs1S5A.jpg Lab Culture - Make it stand out The big D https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/da85920a-1f14-4b7d-9c49-79ca8f16bcb1/Josh_skate.jpeg Lab Culture https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/ee96923a-cdd8-4a41-958b-73a59e574992/Tarun_skate.jpeg Lab Culture https://www.gruberlabutsw.org/rotation-projects daily 0.75 2025-03-22 https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/91827f7a-11ae-484b-bd92-9151886b2d36/chromatin+replication+simpler.jpg https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/7df72676-fe5f-4673-a6e5-808dd87bda47/nUMB_dots_heatmap.jpg https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/f43217d0-5347-469a-a40d-6a68a516ca2a/man-bear-pig.jpg https://www.gruberlabutsw.org/news-press daily 0.75 2023-03-07 https://images.squarespace-cdn.com/content/v1/5ec321c2af33de48734cc929/1618511387030-5LI1E5QMVTQ2RY9S00A4/20140228_Trade+151_0046+1.jpg News & Press https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/bce64fc7-824a-414c-9e57-95f5b9ce8b13/tempImageS6uzuM.jpg https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/c105a286-d461-47ea-aea1-fdaad01c0915/Komen_hackathon_logo.jpeg https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/c13abba2-f9cf-4a53-834a-694f827c8ecf/20200225_tmcx-bootcamp_19-1-scaled-e1607548143143.jpg https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/ba09c1ca-ab79-4a88-bb42-89c266abe41e/Fig5b.jpg https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/9bedeb1c-2fd9-48ab-a2ce-8502bb2e43fa/V-foundation-logo.jpg https://images.squarespace-cdn.com/content/v1/60f5c5c78908bb30722201c3/ef1943ed-34c2-4efc-88e3-fc9c1ae56ac4/man-bear-pig-zoom.png https://www.gruberlabutsw.org/book-a-room daily 0.75 2025-05-09