Publications
Gaddameedi, JD, Geller, BS, Rangarajan, A, Swaminathan, TA, Dixon, D, Long, K, Golder, CJ, Vuong, VA, Banuelos, S, Greenhouse, R, Snyder, MP, Lipchik, AM, Gruber, JJ. Acetyl-Click Screening Platform Identifies Small-Molecule Inhibitors of Histone Acetyltransferase 1 (HAT1). J. Med. Chem. 2023, April 7, 2023. https://doi.org/10.1021/acs.jmedchem.3c00039
Jiang H, Greathouse RL, Tiche SJ, Zhao M, He B, Li Y, Li AM, Forgo B, Yip M, Li A, Shih M, Banuelos S, Zhou MN, Gruber JJ, Rankin EB, Hu Z, Shimada H, Chiu B, Ye J. Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029. PMID: 36318118
Gruber, JJ,# Afgahi, A, DeWees, A, Scott, D, Foran, J, McMillan, A, Ford, JM, Telli, ML.# A phase II study of talazoparib monotherapy in patients with wild-type BRCA1 and BRCA2 with a mutation in other homologous recombination genes. Nat Cancer 3, pages 1181–1191 (2022). #Corresponding.
see News & Views “Expanding biomarkers for PARP inhibitors” by Coussy & Bidard Nat Cancer 3, 1141–1143 (2022)
Thakkar D, Paliwal S, Dharmadhikari B, Guan S, Liu L, Kar S, Tulsian NK, Gruber JJ, DiMascio L, Paszkiewicz KH, Ingram PJ, D Boyd-Kirkup J. Rationally targeted anti-VISTA antibody that blockades the C-C' loop region can reverse VISTA immune suppression and remodel the immune microenvironment to potently inhibit tumor growth in an Fc independent manner. J Immunother Cancer. 2022 Feb;10(2). doi: 10.1136/jitc-2021-003382. PubMed PMID: 35131861; PubMed Central PMCID: PMC8823246.
Sanghi A, Gruber JJ, Metwally A, Jiang L, Reynolds W, Sunwoo J, Orloff L, Chang HY, Kasowski M, Snyder MP. Chromatin accessibility associates with protein-RNA correlation in human cancer. Nat Commun. 2021 Sep 30;12(1):5732. doi: 10.1038/s41467-021-25872-1. PubMed PMID: 34593797; PubMed Central PMCID: PMC8484618.
Gruber, JJ, Rangarajan, A, Chou, T, Geller, BS, Banuelos, S, Greenhouse, R, Snyder, MP, Lipchik, AM. An acetyl-click screening platform identifies a small molecule inhibitor of Histone Acetyltransferase 1 (HAT1) with anti-tumor activity. bioRxiv. doi.org/10.1101/2021.06.25.449993
Liu Q, Wu H, Luo Q-J, Jiang C, Duren Z, Van Bortle K, Zhao M-T, Zhao B, Liu J, Marciano DP, Lee-McMullen B, Zhu C, Narasimha AM, Gruber JJ, Lipchik AM, Guo H, Watson NK, Tsai MS, Furihata T, Tian L, Wei E, Li Y, Steinmetz LM, Wong WH, Kay MA, Wu JC, Snyder MP. Tyrosine kinase inhibitors induce mitochondrial dysfunction during cardiomyocyte differentiation through alteration of GATA4-mediated networks. bioRxiv 2020.05.04.077024
Li Y, Gruber JJ, Litzenburger UM, Zhou Y, Miao YR, LaGory EL, Li AM, Hu Z, Yip M, Hart LS, Maris JM, Chang HY, Giaccia AJ, Ye J. Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia. Cell Death Dis. 2020 Feb 6;11(2):102.
Telli ML, Chu C, Badve SS, Vinayak S, Silver DP, Isakoff SJ, Kaklamani V, Gradishar W, Stearns V, Connolly RM, Ford JM, Gruber JJ, Adams S, Garber J, Tung N, Neff C, Bernhisel R, Timms KM, Richardson AL. Association of Tumor Infiltrating Lymphocytes with Homologous Recombination Deficiency and BRCA1/2 Status in Patients with Early Triple-Negative Breast Cancer: A Pooled Analysis. Clin Cancer Res. 2019 Dec 3. pii: clincanres.0664.2019. doi: 10.1158/1078-0432.CCR-19-0664.
Gruber JJ, Chen J, Geller B, Jäger N, Lipchik AM, Wang G, Kurian AW, Ford JM, Snyder MP. Chromatin Remodeling in Response to BRCA2-Crisis. Cell Rep. 2019 Aug 20;28(8):2182-2193.
Stowers RS, Shcherbina A, Israeli J, Gruber JJ, Chang J, Nam S, Rabiee A, Teruel MN, Snyder MP, Kundaje A, Chaudhuri O. Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility. Nat Biomed Eng. 2019 Dec;3(12):1009-1019.
Gruber JJ, Geller B, Lipchik AM, Chen J, Salahudeen AA, Ram AN, Ford JM, Kuo CJ, Snyder MP. HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding. Mol Cell. 2019 Aug 22;75(4):711-724. *Featured Article.
Accompanied by Preview: Denu, JM. Histone Acetyltransferase 1 Links Metabolism and Transcription to Cell-Cycle Progression. Mol Cell. 2019 Aug 22;75(4):664-665.
Chen J, Haanpää MK, Gruber JJ, Jäger N, Ford JM, Snyder MP. High-Resolution Bisulfite-Sequencing of Peripheral Blood DNA Methylation in Early-Onset and Familial Risk Breast Cancer Patients. Clin Cancer Res. 2019 Sep 1;25(17):5301- 5314.
Gruber JJ, Telli ML. Outstanding Questions in the Clinical Management of Triple- Negative Breast Cancer. J Oncol Pract. 2017 May;13(5):305-7. doi: 10.1200/JOP.2017.023341
Sailani R, Jahanbani F, Nasiri J, Behnam M, Salehi M, Sedghi M, Hoseinzadeh M, Takahashi S, Zia A, Gruber J, Lynch JL, Lam D, Winkelmann J, Amirkiai S, Pang B, Rego S, Mazroui S, Bernstein JA, Snyder MP. Association of AHSG with alopecia and mental retardation (APMR) syndrome. Hum Genet. 2017 Jan 4. doi: 10.1007/s00439-016-1756-5.
Gruber JJ, Colevas AD. Differentiated thyroid cancer: focus on emerging treatments for radioactive iodine-refractory patients. The Oncologist. 2015; 20(2):113-26.
Olejniczak SH, La Rocca G, Gruber JJ, Thompson CB. Long-lived microRNA- Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(1):157-62.
Gruber JJ, Olejniczak SH, Yong J, La Rocca G, Dreyfuss G, Thompson CB. Ars2 promotes proper replication-dependent histone mRNA 3' end formation. Molecular Cell. 2012; 45(1):87-98.
Wise DR, Ward PS, Shay JE, Cross JR, Gruber JJ, Sachdeva UM, Platt JM, DeMatteo RG, Simon MC, Thompson CB. Hypoxia promotes isocitrate dehydrogenase- dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(49):19611-6.
Cash TP, Gruber JJ, Hartman TR, Henske EP, Simon MC. Loss of the Birt-Hogg- Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ- mediated transcription. Oncogene. 2011; 30(22):2534-46.
Zhao F, Mancuso A, Bui TV, Tong X, Gruber JJ, Swider CR, Sanchez PV, Lum JJ, Sayed N, Melo JV, Perl AE, Carroll M, Tuttle SW, Thompson CB. Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprograming. Oncogene. 2010; 29(20):2962-72.
Tong X, Zhao F, Mancuso A, Gruber JJ, Thompson CB. The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(51):21660-5.
Gruber JJ, Zatechka DS, Sabin LR, Yong J, Lum JJ, Kong M, Zong WX, Zhang Z, Lau CK, Rawlings J, Cherry S, Ihle JN, Dreyfuss G, Thompson CB. Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. Cell. 2009; 138(2):328-39.
Sabin LR, Zhou R, Gruber JJ, Lukinova N, Bambina S, Berman A, Lau CK, Thompson CB, Cherry S. Ars2 regulates both miRNA- and siRNA- dependent silencing and suppresses RNA virus infection in Drosophila. Cell. 2009; 138(2):340- 51.
Kong M, Bui TV, Ditsworth D, Gruber JJ, Goncharov D, Krymskaya VP, Lindsten T, Thompson CB. The PP2A-associated protein alpha4 plays a critical role in the regulation of cell spreading and migration. The Journal of biological chemistry. 2007; 282(40):29712-20.
Finnberg N, Gruber JJ, Fei P, Rudolph D, Bric A, Kim SH, Burns TF, Ajuha H, Page R, Wu GS, Chen Y, McKenna WG, Bernhard E, Lowe S, Mak T, El-Deiry WS. DR5 knockout mice are compromised in radiation-induced apoptosis. Molecular and cellular biology. 2005; 25(5):2000-13.
Chen DT, Weeks ER, Crocker JC, Islam MF, Verma R, Gruber J, Levine AJ, Lubensky TC, Yodh AG. Rheological microscopy: local mechanical properties from microrheology. Physical review letters. 2003; 90(10):108301.